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2021 Mercedes-Benz

GLS580 4matic

Auto 9-spd, 8 cyl, 4.0 L, Turbo

Mercedes-Benz GLS580: best and worst years

Overview

Body
Standard Sport Utility Vehicle 4WDEPA, from EPA, last updated 6/22/2026
Drivetrain
4-Wheel DriveEPA, from EPA, last updated 6/22/2026
Transmission
Automatic 9-spdEPA, from EPA, last updated 6/22/2026
Powertrain
HybridEPA, from EPA, last updated 6/22/2026
Fuel
PremiumEPA, from EPA, last updated 6/22/2026

Engine & performance

Cyl
8EPA, from EPA, last updated 6/22/2026
Aspiration
TurbochargedEPA, from EPA, last updated 6/22/2026
Start-stop system
YesEPA, from EPA, last updated 6/22/2026

Efficiency

MPG Hwy
21 mpgEPA, from EPA, last updated 6/22/2026
MPG City
16 mpgEPA, from EPA, last updated 6/22/2026
MPG Comb
18 mpgEPA, from EPA, last updated 6/22/2026
Fuel $/yr
$4,300EPA, from EPA, last updated 6/22/2026
CO₂
491 g/miEPA, from EPA, last updated 6/22/2026
Eco Score
3/10EPA, from EPA, last updated 6/22/2026
Smog score
5/10
Elec. Range
0 miEPA, from EPA, last updated 6/22/2026
SmartWay certified
No

Safety NHTSA, model year

Recalls
0
Owner complaints
0

Known issues manufacturer service bulletins, model year

156 service bulletins filed with NHTSA for this model year

  • May 30, 2026SUSPENSIONPSL-NCU Return Parts 5/29

    Dear Mercedes-Benz USA Dealers, The part numbers listed in the chart below should no longer be installed, and any existing stock must be returned to your facing PDC. The deadline for all dealer returns is no later than Thursday, June 18, 2026. After June 18th, returns of these parts will no longer be accepted. These parts should be returned via ZSR Special Return, using item category SCM Authorized Part Return. Please include a copy of this NCU as your authorization to return these parts. This p

  • May 29, 2026ELECTRICAL SYSTEMLI00.20-P-077615

    Complaint 1. "Perform vehicle handover" in the workshop menu to start the maintenance computer for service A/B cannot be carried out. 2. Service confirmation is not possible because "Perform vehicle handover" is displayed. This cannot be carried out. 3. The service display in the instrument cluster permanently displays 365 days (remaining time) and does not change. Cause Routine change in the software in N133/1 (instrument cluster) or A26/17 (MBUX multimedia system and instrument cluster (head u

  • May 26, 2026ELECTRICAL SYSTEMLI82.85-P-080507

    Complaint After successful commissioning of the HERMES control unit (N112/9) with XENTRY Diagnosis DVD 03/2026, the message "SOS - service not activated" appears on the instrument cluster. In addition, the following two conditions are also met: • HERMES (N112/9) control unit: event code B15CE00 is ACTIVE and STORED (A+S) • Vehicle Documentation System: For the HERMES control unit, the EID1, EID2, ICCID, IMEI, IMSI, TELNR fields in the "Identification/Serial number" column have the value "-" Caus

  • May 22, 2026STRUCTURE:BODYPSL-NCU Return Parts 5/22

    Dear Mercedes-Benz USA Dealers, The part numbers listed in the chart below should no longer be installed, and any existing stock must be returned to your facing PDC. The deadline for all dealer returns is no later than Thursday, June 11, 2026. After June 11th, returns of these parts will no longer be accepted. These parts should be returned via ZSR Special Return, using item category SCM Authorized Part Return. Please include a copy of this NCU as your authorization to return these parts. This p

  • May 22, 2026STEERINGLI46.15-P-070510

    Complaint Noises from the area of the steering column. - Creaking - Squeaking - Chattering - Humming - Grinding Cause At present, there are no known noise problems with the steering column. Remedy Check surrounding area of the steering column for possible noises. • Instrument panel support • Steering column switch module NOTE: Occasionally to verify complaint, the steering column/vehicle needs to be in direct sunlight or hot conditions for a few hours. If noise only occurs when adjusting the ste

  • May 15, 2026SUSPENSIONPSL-NCU Return Parts 5/15

    The part numbers listed in the chart below should no longer be installed, and any existing stock must be returned to your facing PDC. The deadline for all dealer returns is no later than Thursday, June 4, 2026. After June 4th, returns of these parts will no longer be accepted. These parts should be returned via ZSR Special Return, using item category SCM Authorized Part Return. Please include a copy of this NCU as your authorization to return these parts. This procedure will not affect your retu

  • May 13, 2026ELECTRICAL SYSTEMLI82.10-P-080467

    Complaint Despite the IC message shown in these complaints, the primary low-beam function is not restricted. Complaint No. 1: Sporadic "Headlamp Inoperative" message in the instrument cluster (IC), fault code in control unit N10/6 FSAM: • U118A02 communication with the left headlamp range adjustment control unit is faulty. General signal fault. or • U118A08 Communication with the left headlamp range adjustment control unit is faulty. Faulty signal or faulty message. Complaint No. 2: The instrume

  • May 12, 2026BACK OVER PREVENTION: WARNINGSLI54.65-P-080132

    Complaint 1. General Diagnostic Tips 2. One or More PARK Sensor Activations 3. Red Ring Around Vehicle 4. "Active Parking and Parking Assist Inoperative" on Instrument Cluster 5. Cameras 6. Other Park Topics Cause Various root causes Remedy See attached diagnostic guide.

  • and 148 more

Source: NHTSA manufacturer communications (technical service bulletins).

Warranty manufacturer terms, by make

Basic
4 yr / 50k mi
Powertrain
4 yr / 50k mi
Roadside assistance
4 yr / 50k mi
EV battery
10 yr / 155k mi

Information is gathered on a best-effort basis from public sources, may be incomplete or out of date, and is not purchasing or financial advice. Verify with the manufacturer or dealer before buying.